MYCN-induced lineage infidelity initiates SHH medulloblastoma-like tumors outside the canonical lineage of origin
Amplification and high expression of MYCN and MYC are recurrent features of medulloblastoma and other pediatric cancers, yet how these proto-oncogenes interact with developmental programs to initiate tumorigenesis remains unclear. Here, we combine the experimental accessibility of the avian embryo with single-cell transcriptomics to investigate how MYCN overexpression reshapes cerebellar lineage…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
