Hydrogen-Driven Cell-Free Cofactor Regeneration Enables Stoichiometric Bioconversion of Pyruvate to Lactate
The declining cost of green hydrogen, projected below 1.5 USD/kg by 2030, opens new avenues for its use beyond fuel cells and industrial heating. Here we demonstrate that H2 can serve as a stoichiometric electron donor for cell-free enzymatic cofactor regeneration, coupling H2 oxidation to NADPH production and driving the complete bioconversion of pyruvate to lactate. A partially purified enzyme…
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