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XSSDense: Time-resolved X-ray Solution Scattering Density Reconstruction Using a Variational Autoencoder

Solution X-ray scattering provides unique structural information on biomolecules under biological conditions, resolving conformational heterogeneity and time-resolved structural changes. The scattering profiles contain limited information, and interpretation largely relies on fitting candidate structures guided by priors. Direct reconstruction of electron density maps is desirable, but so far has…

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Transcriptome, glycome, and mucinome analysis reveal zinc is essential for the composition of mucus in the human goblet cell model HT-29-MTX

Scientific Reports, Published online: 11 August 2026; doi:10.1038/s41598-026-66227-4 Transcriptome, glycome, and mucinome analysis reveal zinc is essential for the composition of mucus in the human…

  • Zinc deficiency impacts 1 billion globally, causing health issues
  • Zn deficiency alters HT-29-MTX GC transcriptome and mucin synthesis
  • MUC2 and MUC17 levels increase, complex N-glycans decrease in Zn-deficient GCs