VariantFlux: A genotype-first modelling workflow for predicting the impact of genetic variations on human metabolism
Human genetic variation is a major determinant of organ metabolism, yet how naturally occurring variants shape quantitative metabolic phenotypes remains unclear. We present VariantFlux, a workflow that integrates ancestry-aware variant interpretation into genome-scale metabolic modelling to generate personalised, variant-constrained kidney reconstructions. Using the Human1 v1.19 model, we built a…
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