Lymphatic CD49a is a driver of meningeal immune aging and cognitive decline.
Aging is associated with progressive accumulation and dysregulation of dural immune cells, coinciding with impaired CSF drainage and lymphatic function. Prior work has shown that improving lymphatic function in aged mice is sufficient to ameliorate age-associated cognitive decline, and that local immune cells can directly regulate lymphatic draining function. Yet, the endothelial-intrinsic…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
