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Intrauterine growth restriction is associated with adaptive hematopoietic reprogramming and selective immune rewiring in monozygotic twins

Background: Prenatal growth restriction has been associated with adverse neonatal and long-term health outcomes, yet the epigenetic mechanisms by which an adverse intrauterine environment shapes fetal immune development remain incompletely understood. Monozygotic dichorionic-diamniotic twins with selective fetal growth restriction (sFGR) provide a unique human model for investigating…

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Transcriptome, glycome, and mucinome analysis reveal zinc is essential for the composition of mucus in the human goblet cell model HT-29-MTX

Scientific Reports, Published online: 11 August 2026; doi:10.1038/s41598-026-66227-4 Transcriptome, glycome, and mucinome analysis reveal zinc is essential for the composition of mucus in the human…

  • Zinc deficiency impacts 1 billion globally, causing health issues
  • Zn deficiency alters HT-29-MTX GC transcriptome and mucin synthesis
  • MUC2 and MUC17 levels increase, complex N-glycans decrease in Zn-deficient GCs