Altered follicular immunity in secondary lymphoid organs is associated with interferon hyperactivity in Down syndrome
Down syndrome, caused by trisomy 21, is characterized by chronic interferon associated inflammation and immune dysregulation, yet the contribution of human secondary lymphoid organs to shaping this immune landscape remains unclear. Using multimodal single-cell and spatial profiling of human tonsils, we identify extensive remodeling of immune organization in trisomy 21. CD4 T cells are skewed away…
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