A Pseudo-Longitudinal Methylome Projection Framework Defines a Buccal PACE-like Aging-Rate Score from Cross-Sectional DNA Methylation Data
Background: DNA methylation-based biomarkers have enabled robust estimation of biological age across tissues, and longitudinally trained measures such as DunedinPACE provide estimates of the pace of aging from blood methylomes. However, longitudinal methylation data are often unavailable, particularly for minimally invasive tissues such as buccal mucosa. Here, we developed a pseudo-longitudinal…
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