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A map of human protein-protein interaction embeddings for functional discovery

A protein's function depends not just on its own structure and localization, but also on the interactions with its partners. Many proteins are therefore better described by a set of partner-dependent roles than by a single annotation. Yet most approaches to the functional interpretation of protein-protein interactions (PPIs) remain protein or set-centric. They rely on pre-existing annotations,…

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Transcriptome, glycome, and mucinome analysis reveal zinc is essential for the composition of mucus in the human goblet cell model HT-29-MTX

Scientific Reports, Published online: 11 August 2026; doi:10.1038/s41598-026-66227-4 Transcriptome, glycome, and mucinome analysis reveal zinc is essential for the composition of mucus in the human…

  • Zinc deficiency impacts 1 billion globally, causing health issues
  • Zn deficiency alters HT-29-MTX GC transcriptome and mucin synthesis
  • MUC2 and MUC17 levels increase, complex N-glycans decrease in Zn-deficient GCs