{
  "id": 981047,
  "title": "DJ-1/PARK7 Determines miRNA Network Plasticity During Genotoxic Stress",
  "url": "https://urgent.news/2026/08/14/dj-1-park7-determines-mirna-network-plasticity-during-genotoxic-stress",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.10.744036v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "PARK7 (DJ-1) is a redox-sensitive protein that supports cellular adaptation, but its role in post-transcriptional responses to genotoxic stress remains unclear. We investigated whether DJ-1 abundance determines the miRNA response to X-ray-induced DNA damage. Integrated mRNA-seq and small RNA-seq across DJ-1 states in HEK293 cells revealed a striking divergence in miRNA plasticity. DJ-1 depletion…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}