{
  "id": 9791492,
  "title": "Stroke Remodels Tumor Microenvironment to Promote Glioma Growth",
  "url": "https://urgent.news/2026/09/25/stroke-remodels-tumor-microenvironment-to-promote-glioma-growth",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-25T16:37:54.000Z",
  "source": {
    "name": "GEN Biotechnology",
    "slug": "gen-biotechnology",
    "url": "https://www.genengnews.com/topics/cancer/stroke-remodels-tumor-microenvironment-to-promote-glioma-growth/"
  },
  "original_language": "en",
  "account": "A study conducted by researchers at Texas Children’s Duncan Neurological Research Institute and Baylor College of Medicine has found that stroke can promote the growth of glioma, a malignant brain tumor. The team used mouse and human models to investigate the cellular and molecular mediators involved in this process. They discovered that stroke induces remodeling of the tumor microenvironment (TME), alongside the emergence of a distinct population of tumor-associated astrocytes (TAAs) with reduced calcium activity. This was accompanied by an accumulation of tumor-associated microglia and macrophages (TAMs). The researchers found that restoring TAAs' calcium signaling or depleting TAMs could suppress stroke-induced glioma progression, indicating the importance of these cell types in the injury response. Lead researcher Dr. Hyun Kyoung Lee noted that recent clinical studies have shown a correlation between glioma and brain injuries, with patients who have experienced ischemic stroke being at an increased risk of developing brain tumors, with a risk factor ranging from three to seven times higher. The study, published in Nature Cancer, suggests that targeting injury-induced tumor-promoting pathways could be a potential therapeutic approach for reducing the risk of glioma growth in patients with a history of brain injury.",
  "summary": "A study in mouse and human models showed how stroke promotes glioma growth by remodeling the tumor microenvironment, with the emergence of a distinct population of tumor-associated astrocytes with reduced Ca 2+ activity, and enrichment of tumor-associated microglia and macrophages (TAMs). The post Stroke Remodels Tumor Microenvironment to Promote Glioma Growth appeared first on GEN - Genetic…",
  "key_points": [
    "Stroke remodels tumor microenvironment to promote glioma growth",
    "Stroke induces remodeling of TME and distinct TAAs with reduced calcium activity",
    "Restoring TAAs calcium signaling or depleting TAMs suppresses stroke-induced glioma"
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}