{
  "id": 974525,
  "title": "A Toolbox for Binary and Rheostat-like Modulation of TOX Expression via Genome and Epigenome Editing in Primary Human T cells",
  "url": "https://urgent.news/2026/08/14/a-toolbox-for-binary-and-rheostat-like-modulation-of-tox-expression",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-08-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.13.744691v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "T cells, which are central mediators of the adaptive immune response, can become dysfunctional when faced with persistent antigen stimulation, such as in chronic infections and cancer. This dysfunctional state, known as T cell exhaustion, limits pro-inflammatory T cell function, dampens cytotoxicity and proliferative capacity, and promotes expression of inhibitory receptors. Thymocyte…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "Phys.org",
        "title": "Genome study reveals centromeres as one of the fastest-changing regions in human DNA",
        "url": "https://urgent.news/2026/08/11/genome-study-reveals-centromeres-as-one-of-the-fastest-changing",
        "published": "2026-08-11T19:20:02.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}