{
  "id": 9718169,
  "title": "Human memory CD4+ T cells recognize non-infected macrophage bystanders exposed to Mycobacterium tuberculosis-infected cells",
  "url": "https://urgent.news/2026/09/24/human-memory-cd4-t-cells-recognize-non-infected-macrophage-bystanders",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-24T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.19.752467v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Control of Mycobacterium tuberculosis (Mtb) infection requires CD4+ T cell recognition of infected macrophages. However, T cells also colocalize with non-infected macrophages in granulomas. We investigated whether these bystander macrophages present Mtb antigens and shape human CD4+ T cell responses. Using ex vivo co-culture systems, non-infected monocyte-derived macrophages (MDMs) were exposed…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "bioRxiv",
        "title": "LL-37 and Citrullinated-LL-37 elicited Transcriptome and Cytokine Profiles in Human Bronchial Epithelial Cells: Citrullination dampens the inflammatory biosignature",
        "url": "https://urgent.news/2026/09/25/ll-37-and-citrullinated-ll-37-elicited-transcriptome-and-cytokine",
        "published": "2026-09-25T00:00:00.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}