{
  "id": 9697137,
  "title": "Abnormally low expression of tumor necrosis factor stimulated gene 6 (TSG-6) in obese type 2 diabetic mice contributes to altered inflammation and delayed cutaneous wound healing",
  "url": "https://urgent.news/2026/09/24/abnormally-low-expression-of-tumor-necrosis-factor-stimulated-gene-6",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-24T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.19.752893v1?rss=1"
  },
  "original_language": "en",
  "account": "Type 2 diabetes mellitus (T2DM) is a chronic condition linked to obesity and high blood sugar levels. The disease is associated with adverse health outcomes, including delayed wound healing and the development of diabetic foot ulcers. Tumor necrosis factor-stimulated gene 6 (TSG-6) is a protein that plays a role in regulating cytokine binding to glycosaminoglycans in extracellular matrices and on vascular endothelial walls. Previous research has shown that a deficiency of TSG-6 in knockout mice leads to increased skin inflammation and slower wound healing. In this study, researchers investigated the effects of TSG-6 on wound healing in two models of diabetes: a genetic model using db/db mice and a dietary model using mice fed a high-fat diet (HFD) and treated with streptozotocin (STZ). Both models resulted in sustained hyperglycemia and a delay in wound closure. The research found that TSG-6 expression was significantly reduced in diabetic skin in both models, both before and after wounding. Wounds in HFD+STZ diabetic mice exhibited higher levels of pro-inflammatory cytokines (IL-6, TNF-, and MIP-1) and lower levels of the anti-inflammatory cytokine IL-10, compared to wounds in normoglycemic mice. The reintroduction of TSG-6 protein into the wounds helped to normalize healing rates, correct abnormal cytokine expression levels, and increase macrophage accumulation in the dermal and adipose compartments. The findings suggest that reduced levels of TSG-6 in diabetic skin contribute to the pro-inflammatory environment and delay in wound closure.",
  "summary": "Type 2 diabetes mellitus (T2DM) is a chronic disorder associated with obesity and hyperglycemia. T2DM is linked to significant clinical complications such as delayed wound healing and diabetic foot ulcers. Tumor necrosis factor-stimulated gene 6 (TSG-6) is a protein with multiple functions including regulation of cytokine binding to glycosaminoglycans in extracellular matrices and on vascular…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}