{
  "id": 9669137,
  "title": "Fluoxetine Hydrochloride Treatment Influences Site-Specific ADAR Editing and Transcriptome Regulation in Arid1b +/- Mice",
  "url": "https://urgent.news/2026/09/24/fluoxetine-hydrochloride-treatment-influences-site-specific-adar",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-24T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.24.753309v1?rss=1"
  },
  "original_language": "en",
  "account": "Fluoxetine hydrochloride treatment, a type of Selective Serotonin Reuptake Inhibitor (SSRI), alters site-specific editing rates in the double-stranded RNA of mice with a genetic mutation called Arid1b. This finding is relevant to Autism Spectrum Disorder (ASD) research, as ASD is characterized by transcriptome-wide dysregulations such as differential gene expression and alternative splicing. The use of SSRIs can lead to changes in microRNA-mRNA interactions, which in turn can influence neurotransmission. The study of these editing rates in mice provides insight into potential mechanisms behind ASD pathology.",
  "summary": "Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by repetitive behavior and impaired social interactions. Recent reports from human postmortem brain samples of ASD show transcriptome-wide dysregulations, including changes in differential gene expression and alternative splicing. An important mechanism regulating transcriptome function is the editing of double-stranded…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}