{
  "id": 9662087,
  "title": "Two Ume6 target gene classes in the biofilm regulatory network of Candida albicans",
  "url": "https://urgent.news/2026/09/24/two-ume6-target-gene-classes-in-the-biofilm-regulatory-network-of",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-24T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.24.753443v1?rss=1"
  },
  "original_language": "en",
  "account": "Biofilm formation by the fungal pathogen Candida albicans causes significant infection issues. The biofilm regulator Ume6 interacts with transcription factors Efg1, Ndt80, and Upc2 to activate biofilm-related gene expression. Through chromatin immunoprecipitation with sequencing (ChIP-seq) data analysis, researchers discovered that Ume6 associates with two promoter region classes in both wild-type and efg1{Delta}/{Delta} ndt80{Delta}/{Delta} upc2{Delta}/{Delta} backgrounds. In one class, Ume6 association decreases significantly in the triple mutant background, encompassing 577 genes with established roles in biofilm formation or filamentation. The second class of genes, with 534 members, remains unaffected by Ume6 association in the triple mutant background. These genes have ties to iron homeostasis, such as SFU1, and ergosterol synthesis, like ERG11, which could contribute to Ume6's influence on ntd80{Delta}/{Delta} mutant drug sensitivity. Additionally, this class includes FLO9, a potential adhesin gene crucial for the biofilm state in efg1{Delta}/{Delta} ndt80{Delta}/{Delta} double mutants. The findings indicate that Ume6 binding to approximately half of its targets requires known partners, while the other half of the targets do not require such partners. Ume6 may bind to the latter set of promoter regions independently or with undiscovered additional partners.",
  "summary": "Biofilm formation by the fungal pathogen Candida albicans is a major source of infection. The biofilm regulator Ume6 forms complexes with partner transcription factors Efg1, Ndt80, and Upc2 to drive expression of biofilm-related genes. Here we present chromatin immunoprecipitation with sequencing (ChIP-seq) data for Ume6-chromatin association in both wild-type and efg1{Delta}/{Delta}…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}