{
  "id": 961389,
  "title": "Conformational selection drives substrate-ATP coupling in the type VI ABC transporter",
  "url": "https://urgent.news/2026/08/14/conformational-selection-drives-substrate-atp-coupling-in-the-type-vi",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.11.744245v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "The mechanism of substrate-ATP coupling is central to the function of ABC transporters. Substrates bind to the specialized transmembrane domains (TMDs), whereas ATP binding and hydrolysis occur in the conserved intracellular nucleotide-binding domains (NBDs). Efficient substrate transport requires coupling between these processes, in which the intracellular coupling helices play an essential…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}