{
  "id": 9571873,
  "title": "How the APOE4 gene damages brain blood vessels in Alzheimer's disease",
  "url": "https://urgent.news/2026/09/24/how-the-apoe4-gene-damages-brain-blood-vessels-in-alzheimers-disease",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-24T15:00:05.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-09-apoe4-gene-brain-blood-vessels.html"
  },
  "original_language": "en",
  "account": null,
  "summary": "Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease. Published in Cell and Cell Stem Cell, the studies identify potentially reversible disease mechanisms and demonstrate how a new stem cell-derived human brain tissue platform…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 3,
    "also_reported_by": [
      {
        "outlet": "PsyPost",
        "title": "Alzheimer’s proteins predict early brain shrinkage before dementia symptoms appear",
        "url": "https://urgent.news/2026/09/23/alzheimers-proteins-predict-early-brain-shrinkage-before-dementia",
        "published": "2026-09-23T22:00:30.000Z"
      },
      {
        "outlet": "bioRxiv",
        "title": "The balance of local and distributed excitation shapes brain stability and reflects aging- and Alzheimer's disease-related alterations",
        "url": "https://urgent.news/2026/09/24/the-balance-of-local-and-distributed-excitation-shapes-brain",
        "published": "2026-09-24T00:00:00.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}