{
  "id": 9500773,
  "title": "Structural Adaptability in HIV-2 Vif Drives Broad Antagonism of APOBEC3G",
  "url": "https://urgent.news/2026/09/23/structural-adaptability-in-hiv-2-vif-drives-broad-antagonism-of",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-23T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753272v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "APOBEC3G (A3G), a restriction factor, is a barrier for zoonosis and targeted for degradation by the lentiviral protein Vif. Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 arose from transmissions of lentiviruses from Old World monkeys to hominid primates. While HIV-1 Vif needed to adapt to specific residues in the arms race interface with A3G, HIV-2 Vif has greater tolerance for diversity…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}