{
  "id": 9452202,
  "title": "Impaired Peroxisome Import Drives Cellular Senescence through SCAF1-Dependent Suppression of Mitoribosome Biogenesis",
  "url": "https://urgent.news/2026/09/23/impaired-peroxisome-import-drives-cellular-senescence-through-scaf1",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-23T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.19.752713v1?rss=1"
  },
  "original_language": "en",
  "account": "Peroxisomes and mitochondria work together to maintain cellular metabolic balance. However, the effect of peroxisomal import stress on mitochondrial function during aging and cellular senescence is not yet understood. Researchers used a genome-wide CRISPR screen in HEK293 cells, and identified SCAF1 (a splicing factor) as a critical regulator of mitochondrial homeostasis under peroxisomal stress. When exposed to peroxisomal stress, SCAF1 undergoes a proteolytic change and moves to the mitochondria. Here, its N-terminal part functions as an independent inhibitor, preventing the assembly of mitoribosomal subunits. When SCAF1 is removed, this process speeds up, increasing the levels of proteins involved in oxidative phosphorylation. Conversely, when SCAF1 is overexpressed in fibroblasts, it triggers cellular senescence, marked by increased \"beta\" gal staining. These results reveal a signaling pathway from peroxisomes to mitochondria, mediated by SCAF1, which controls mitoribosome assembly to sustain translational equilibrium. This pathway provides a molecular explanation for how the decline in peroxisomal function can lead to mitochondrial dysfunction and cellular aging.",
  "summary": "Communication between peroxisomes and mitochondria is essential for cellular metabolic homeostasis, yet how peroxisomal import stress impacts mitochondria function during aging and cellular senescence remains poorly defined. Using a genome-wide CRISPR screening in HEK293 cells under peroxisome import stress, we identified SCAF1 (SR-related CTD-associated factor 1) a known canonical nuclear…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}