{
  "id": 9409795,
  "title": "High-fat diets suppress enzyme in immune cells, promoting fat tissue inflammation in mice",
  "url": "https://urgent.news/2026/09/23/high-fat-diets-suppress-enzyme-in-immune-cells-promoting-fat-tissue",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-23T20:40:08.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-09-high-fat-diets-suppress-enzyme.html"
  },
  "original_language": "en",
  "account": "Obese mice exhibit increased fatty acid uptake in their immune cells, leading to the suppression of a crucial enzyme called acetyl-CoA carboxylase 1 (ACC1). This inhibition disrupts the maintenance and function of group 2 lymphoid cells (ILC2) in adipose tissue, contributing to inflammation and enlargement of fat tissue. The research from the University Hospital Bonn and the University of Bonn reveals that ACC1 plays a key role in balancing lipid metabolism and energy production within ILC2 cells. When mice consume a high-fat diet, the enzyme is inhibited, impairing the cells' ability to produce energy and maintain a healthy inflammatory response. This self-reinforcing mechanism highlights the importance of considering immune cell metabolism in the development of obesity and diabetes treatments.",
  "summary": "A group of innate immune cells, known as group 2 lymphoid cells (ILC2), are essential for maintaining a stable metabolism in adipose tissue. Obesity significantly impairs the number and function of ILC2 cells, leading to the progression of metabolism-related inflammation. Until now, it was unknown how ILC2 cells are disrupted in obesity.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}