{
  "id": 9353273,
  "title": "Large-scale studies create one of the world's most comprehensive single-cell atlases of human brain disease",
  "url": "https://urgent.news/2026/09/23/large-scale-studies-create-one-of-the-worlds-most-comprehensive",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-23T15:00:16.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-09-large-scale-world-comprehensive-cell.html"
  },
  "original_language": "en",
  "account": "This groundbreaking collection of nine papers, published across the Nature family of journals, marks one of the most comprehensive single-cell atlases of human brain disease to date. Led by Mount Sinai scientists within the PsychAD Consortium, a multidisciplinary initiative supported by the National Institute on Aging, the research unveils shared and disease-specific molecular changes underlying Alzheimer's disease, Parkinson's disease, schizophrenia, and other brain disorders.\n\nThe centerpiece of the collection is a Nature study generating a population-scale single-cell atlas of the human dorsolateral prefrontal cortex. Using over 6.3 million cell nuclei from 1,494 human donors, the study identified both common molecular programs and disease-specific signatures across various cell types, such as neuronal, glial, immune, and vascular cells. It also mapped cellular trajectories associated with disease progression and neuropsychiatric symptoms.\n\nThis atlas establishes a foundational resource, enabling researchers worldwide to explore how cellular and molecular mechanisms contribute to neurological and psychiatric disorders. The goal is to accelerate the development of targeted therapies by deepening the understanding of the molecular complexity underlying brain diseases.",
  "summary": "Research led by Mount Sinai scientists within the PsychAD Consortium, a large-scale, multidisciplinary initiative launched in 2019 with support from the National Institute on Aging (NIA), is featured in a collection of nine papers published across the Nature family of journals that maps the molecular mechanisms underlying Alzheimer's disease, Parkinson's disease, schizophrenia and other brain…",
  "key_points": [
    "Mount Sinai-led PsychAD Consortium publishes nine papers in Nature journals",
    "Study generates population-scale single-cell atlas of dorsolateral prefrontal cortex",
    "Atlas reveals common and disease-specific molecular changes in brain disorders"
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}