{
  "id": 9228268,
  "title": "RNA self-association limits the removal of double-stranded RNA by affinity chromatography",
  "url": "https://urgent.news/2026/09/22/rna-self-association-limits-the-removal-of-double-stranded-rna-by",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-22T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.749193v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Double-stranded RNAs are inflammatory byproducts of in vitro transcription of single-stranded RNA. Here we investigate removal of dsRNA byproducts using dsRNA affinity chromatography (dsRNA-AC) and two mRNA molecules with contrasting biophysical properties: 1) GFP, and 2) high dsRNA wild-type firefly luciferase (fLucWT). For GFP mRNA, dsRNA reduction was strong, and mRNA recovery was high. In…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}