{
  "id": 9213943,
  "title": "Parental B-MYB/FOXM1 controls mitotic E2F to determine daughter cell fate",
  "url": "https://urgent.news/2026/09/22/parental-b-myb-foxm1-controls-mitotic-e2f-to-determine-daughter-cell",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-22T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753170v1?rss=1"
  },
  "original_language": "en",
  "account": "Parental B-MYB/FOXM1 activation controls mitotic E2F levels to determine whether a cell continues cycling or exits the cell cycle after the restriction point, according to a new study. Researchers have developed a dual transcriptional biosensor system to investigate how mitogens regulate the timing of B-MYB/FOXM1 activation and its impact on cell-cycle progression. Their findings reveal that S/G2 phase duration is determined by the precise timing of B-MYB/FOXM1 activation, while E2F activity gradually diminishes before mitosis. Rapid B-MYB/FOXM1 activation leads to shorter S/G2 phases and high mitotic E2F activity in daughter cells, keeping them cycling. Conversely, delayed B-MYB/FOXM1 activation results in longer S/G2 phases, reducing mitotic E2F levels and driving daughter cells into quiescence. If S/G2 remains prolonged, partially activated B-MYB/FOXM1 can revert, triggering mitotic bypass and potentially leading to polyploid quiescence. In summary, B-MYB/FOXM1 plays a critical role in governing cell fate by establishing a tri-directional control mechanism at the G2 restriction point.",
  "summary": "Mitogens trigger cell-cycle entry by activating E2F at the restriction point, which is followed by B-MYB/FOXM1 activation and progression to mitosis. How mitogens control continued cycling and cell-cycle exit after the restriction point is not well-understood. By developing an E2F and B-MYB/FOXM1 dual transcriptional biosensor system, we show that S/G2 phase duration is set by timed…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}