{
  "id": 9206713,
  "title": "ALDH2 Knockout Induces Dysregulation of Arginine biosynthesis in SKBR-3 Breast Cancer Cells",
  "url": "https://urgent.news/2026/09/22/aldh2-knockout-induces-dysregulation-of-arginine-biosynthesis-in-skbr",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-22T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753265v1?rss=1"
  },
  "original_language": "en",
  "account": "Background: Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that helps mitigate cellular stress by detoxifying reactive aldehydes. Individuals with ALDH2*2 polymorphism, which leads to reduced catalytic activity, are more likely to develop cancer and other diseases. The metabolic dysregulations caused by ALDH2 deficiency have not been extensively studied.\n\nMethods: Researchers created an ALDH2 knockout subline of SKBR-3 cells using the CRISPR/Cas9 strategy. The metabolomic profiles of the control (SKBR-3/C) and ALDH2 knockout (SKBR-3/ADKO) cells were assessed through ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS).\n\nResults: The ALDH2 knockout in SKBR-3 cells led to increased cellular stress, with elevated levels of 8-OHdG, reactive oxygen species (ROS), and malondialdehyde (MDA). A total of 5,033 signals were analyzed, with 281 significantly different (fold change ≥ 2, p-value).",
  "summary": "Background/Objectives: Aldehyde dehydrogenase 2 (ALDH2), a mitochondrial enzyme, mitigates cellular stress by detoxifying reactive aldehydes produced during alcohol exposure and endogenous metabolic processes. ALDH2*2 polymorphism, which results in deficient catalytic activity, is prevalent in East Asian populations and is associated with an increased risk of cancer and other diseases. While the…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}