{
  "id": 9176666,
  "title": "Molecular Architecture of the Human GCN1-ABCF3 Ribosome Collision Sensor",
  "url": "https://urgent.news/2026/09/22/molecular-architecture-of-the-human-gcn1-abcf3-ribosome-collision",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-22T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.19.752920v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "The Integrated Stress Response is a critical eukaryotic signaling pathway that maintains cellular proteostasis. During amino acid scarcity, the yeast kinase Gcn2 (GCN2 in humans) and its activators Gcn1/Gcn20 phosphorylate eIF2 to reprogram translation, but how GCN2 senses nutrient stress in mammals is not known. Ribosome collisions serve as a major physiological trigger. Here we report a cryo-EM…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}