{
  "id": 9176643,
  "title": "Maintaining transcriptome solubility constrains mRNA sequence composition",
  "url": "https://urgent.news/2026/09/14/maintaining-transcriptome-solubility-constrains-mrna-sequence",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-14T07:00:00.000Z",
  "source": {
    "name": "PNAS",
    "slug": "pnas",
    "url": "https://www.pnas.org/doi/abs/10.1073/pnas.2622980123?af=R"
  },
  "original_language": "en",
  "account": null,
  "summary": "Proceedings of the National Academy of Sciences, Volume 123, Issue 38, September 2026. SignificanceRNA base-pairing enables folding and regulation, but it also creates pervasive opportunities for unintended RNA–RNA interactions in the crowded intracellular environment. We identify this as a transcriptome-scale physical problem. Simulations ...",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}