{
  "id": 9153026,
  "title": "A fibroblast-rich transcriptomic axis reflects stromal remodeling within the CMS4 phenotype in colorectal cancer",
  "url": "https://urgent.news/2026/09/22/a-fibroblast-rich-transcriptomic-axis-reflects-stromal-remodeling",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-22T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.18.752659v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Bulk-tumor expression signatures can reflect cellular composition as well as tumor-cell programs. We evaluated a frozen, equal-weight 87-gene score in colorectal cancer using 11 Gene Expression Omnibus (GEO) cohorts, TCGA COAD/READ, and E-MTAB-12862. In GEO (1,783 tumors; 441 progression-related events), the hazard ratio per score standard deviation was 1.33 (95% confidence interval, 1.19-1.49).…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}