{
  "id": 913753,
  "title": "MAFB is essential for the maintenance of adult human α-cell identity and glucagon secretion",
  "url": "https://urgent.news/2026/08/14/mafb-is-essential-for-the-maintenance-of-adult-human-cell-identity",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.08.743687v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Dysregulated hormone secretion and erosion of endocrine cell identity are features of type 1 and type 2 diabetes, but the transcriptional programs maintaining adult human islet identity and function remain poorly defined. The large MAF transcription factor MAFB is expressed in human - and {beta}-cells, marks their most functionally mature subpopulations, and is downregulated in diabetes, but its…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}