{
  "id": 9130290,
  "title": "Endothelium-on-a-chip for permeability studies in diabetic and diabetic kidney disease milieu",
  "url": "https://urgent.news/2026/09/22/endothelium-on-a-chip-for-permeability-studies-in-diabetic-and",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-22T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.18.752765v1?rss=1"
  },
  "original_language": "en",
  "account": "Endothelium-on-a-chip (EoaC) technology, a valuable tool in research, enables faithful replication of target tissues or organs by incorporating essential physiological cues that cells experience in their natural environment. In this study, researchers developed an EoaC specifically for examining endothelial barrier permeability in diabetic and diabetic kidney disease (DKD) conditions under realistic shear stress.\n\nTo measure permeability, the fluorescently labeled macromolecular tracer flux assay was employed, resulting in apparent permeability (Papp) values. The researchers tested the protective effects of shear stress in diabetic and DKD conditions by individually exposing the EoaC to endogenous diabetic factors, such as hyperglycemia, and pro-inflammatory factor TNF[a], as well as hypertension-related hormone aldosterone. They also examined the combined impact of aldosterone in hyperglycemia and a DKD mix consisting of TNF[a] and aldosterone in hyperglycemia.\n\nFurthermore, the researchers assessed the EoaC's potential for drug testing by introducing the mineralocorticoid receptor antagonist, finerenone, which demonstrated a statistically significant protective effect on endothelial barrier integrity in DKD milieu. The study concludes that the EoaC can be effectively utilized for evaluating endothelial barrier permeability not only in diabetic and DKD conditions but also in various other pathophysiological situations. Additionally, the EoaC holds promise for targeted drug testing aimed at enhancing endothelial barrier resilience.",
  "summary": "Organ-on-a-chip (OOC) technology is a valuable tool that can facilitate a faithful replication of target tissues or organs by enabling the application of important physiological cues that cells experience in their native environment. We describe here an endothelium-on-a-chip that was developed for studying endothelial barrier permeability in diabetic and diabetic kidney disease (DKD) milieu under…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}