{
  "id": 9130282,
  "title": "TFE3 fusions drive expression of CD44 and SPP1 in Translocation Renal Cell Carcinoma",
  "url": "https://urgent.news/2026/09/22/tfe3-fusions-drive-expression-of-cd44-and-spp1-in-translocation-renal",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-22T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.18.752493v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Xp11.2 translocation RCC [Xp11.2 tRCC]) is an underdiagnosed and aggressive subtype of RCC with few specific or targeted therapies. The transmembrane glycoprotein CD44 is an emerging target in many advanced malignancies, and with its ligand OPN (SPP1), is a crucial driver of cancer progression, stemness, metastasis, and immune suppression. Here we show that common TFE3-fusions [ including…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}