{
  "id": 9079993,
  "title": "The impact of alpha synuclein overexpression on nigrostriatal transmission",
  "url": "https://urgent.news/2026/09/21/the-impact-of-alpha-synuclein-overexpression-on-nigrostriatal",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-21T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751842v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Accumulation of wild type synuclein in dopamine neurons of the Substantia Nigra pars compacta is a pathological hallmark of Parkinson's disease (PD), which commonly precedes neurodegeneration. Yet how synuclein accumulation affects nigrostriatal neurotransmission early in the progression of PD remains poorly understood. In addition to axonal dopamine release, SNc neurons also co-release GABA and…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}