{
  "id": 9079983,
  "title": "Diversity of penicillin-binding protein 2x in Streptococcus pyogenes from England and Wales, 2001 to 2015",
  "url": "https://urgent.news/2026/09/21/diversity-of-penicillin-binding-protein-2x-in-streptococcus-pyogenes",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-21T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.752073v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Streptococcus pyogenes remains clinically susceptible to {beta}-lactam antibiotics, its first-line treatment. Yet recent reports from the US, Iceland, and Japan have identified isolates with PBP2x (a primary {beta}-lactam target) substitutions that reduced antibiotic susceptibility. To determine whether these PBP2x substitutions occurred in S. pyogenes from England and Wales, we re-analysed 2,970…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "bioRxiv",
        "title": "Temporal changes in platelet activation and organ dysfunction during invasive Streptococcus pyogenes infection",
        "url": "https://urgent.news/2026/09/19/temporal-changes-in-platelet-activation-and-organ-dysfunction-during",
        "published": "2026-09-19T00:00:00.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}