{
  "id": 906995,
  "title": "A microbiota-responsive polyfunctional cytotoxic CD4+ T-cell state promotes mucosal inflammation in ulcerative colitis",
  "url": "https://urgent.news/2026/08/14/a-microbiota-responsive-polyfunctional-cytotoxic-cd4-t-cell-state",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.10.743953v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Ulcerative colitis (UC) is characterised by chronic colonic inflammation with marked heterogeneity in disease severity and therapeutic outcomes. Here, we define a spatially organised, polyfunctional cytotoxic CD4+ T-cell state associated with mucosal inflammation and adverse therapeutic outcomes in UC. Integrating ex vivo T-cell receptor stimulation with multi-cohort bulk and single-cell…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}