{
  "id": 8828620,
  "title": "Tissue-Resident and Effector-Memory Lymphocyte Recruitment to the Ocular Mucosa Requires CCL28/CCR10 Signaling During Recurrent HSV-1 Infection",
  "url": "https://urgent.news/2026/09/20/tissue-resident-and-effector-memory-lymphocyte-recruitment-to-the",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-20T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.14.751393v1?rss=1"
  },
  "original_language": "en",
  "account": "Ocular herpes simplex virus type 1 (HSV-1) infection can cause chronic inflammation and vision loss, and effective antiviral immunity is crucial for controlling the virus and preventing recurrent disease. Scientists studied the mechanisms behind the recruitment of protective lymphocytes to the ocular mucosa (OM) during recurrent HSV-1 infection using a mouse model. They discovered that the CCL28/CCR10 axis plays a vital role in mobilizing these immune cells to the OM.\n\nIn wild-type mice, CCL28 expression increased in the OM following HSV-1 infection, leading to the accumulation of HSV-specific effector-memory T cells and CCR10+B220+ B cells. These cells had an antigen-experienced, effector-memory phenotype, indicating that CCL28/CCR10 signaling contributes to a localized antiviral immune response in the ocular mucosa.\n\nIn contrast, mice lacking CCL28 (CCL28(-/-)) were more susceptible to recurrent HSV-1 infection. They had significantly reduced frequencies of HSV-specific effector-memory T cells, tissue-resident memory T cells, and CCR10+B220+ B cells in the infected OM and trigeminal ganglia (TG). These mice also showed diminished effector function, including lower production of IFN-γ, TNF, and Granzyme B, leading to increased viral burden and ocular pathology.\n\nThese findings reveal the CCL28/CCR10 axis as a crucial regulator of antiviral B- and T-cell trafficking to the ocular mucosa, which is essential for protection against recurrent herpetic eye disease. This discovery offers a mechanistic basis for using mucosal chemokine pathways to improve vaccine strategies against ocular herpes.",
  "summary": "Ocular herpes simplex virus type 1 (HSV-1) infection is a major cause of infectious corneal disease that can lead to recurrent herpetic keratitis, chronic inflammation, and vision loss. Although effective antiviral immunity is essential for controlling HSV-1 and limiting recurrent disease, the mechanisms regulating recruitment of protective lymphocytes to the ocular mucosa remain incompletely…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}