{
  "id": 8608783,
  "title": "Ile35 residue of SOD1 plays a key role in aggregate formation and eye degeneration in a Drosophila model of ALS",
  "url": "https://urgent.news/2026/09/19/ile35-residue-of-sod1-plays-a-key-role-in-aggregate-formation-and-eye",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-19T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.13.751333v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "{middle dot}The pathophysiology of ALS caused by mutant SOD1 remains unclear. {middle dot}We previously demonstrated, using the BioID2-EGFP sandwich expression system in cultured cells, that the Ile35 residue of ALS-linked mutant SOD1 promotes its aggregate formation. {middle dot}However, the precise role of the SOD1 Ile35 residue in aggregate formation and neurodegeneration in vivo remained…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}