{
  "id": 8608779,
  "title": "Optimizing the connectivity of protein conformations to untangle ensemble refinement",
  "url": "https://urgent.news/2026/09/19/optimizing-the-connectivity-of-protein-conformations-to-untangle",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-19T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.17.752399v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Proteins naturally adopt multiple conformations in mediating cellular processes, and ensemble models are used to fit X-ray crystallography data that captures this heterogeneity. In practice, ensemble refinement produces only minor improvements in agreement with experimental data (R-free) over single-conformation models. It has recently been shown that ensemble models are universally trapped, or…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}