{
  "id": 8381222,
  "title": "Closed-loop steering locates an evolutionary barrier to multidrug resistance in Escherichia coli",
  "url": "https://urgent.news/2026/09/18/closed-loop-steering-locates-an-evolutionary-barrier-to-multidrug",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-18T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.17.752270v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Resistance to one drug often raises susceptibility to another; such collateral sensitivity is expected to constrain multidrug resistance. This is hard to test: failure to reach a state is indistinguishable from never having been driven toward it. We therefore recorded the change we imposed: a closed-loop system updated each lineage's drug environment daily based on its measured distance to a…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}