{
  "id": 829937,
  "title": "Inflammatory proteolysis generates pathogenic APOL1 fragments with distinct intracellular toxicities in podocytes derived from children with HIV associated nephropathy.",
  "url": "https://urgent.news/2026/08/13/inflammatory-proteolysis-generates-pathogenic-apol1-fragments-with",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-08-13T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.12.744497v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "APOL1 risk variants are the strongest genetic determinants of HIV-associated nephropathy (HIVAN), yet the mechanisms linking inflammation to APOL1-mediated podocyte injury remain poorly understood because authentic patient-derived human disease models are lacking. Using urine-derived podocytes established from children with HIVAN and endogenous APOL1 reporter cell lines derived from these cells,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}