{
  "id": 829936,
  "title": "Outside-in progression of heterochromatin replication and exclusion of CDC45 from the PCH domain in Drosophila",
  "url": "https://urgent.news/2026/08/13/outside-in-progression-of-heterochromatin-replication-and-exclusion",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-13T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.13.744572v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Heterochromatin replication isn't random or uniform, but occurs in a characteristic spatial and temporal pattern. Previous studies produced conflicting models for pericentric heterochromatin (PCH) replication, suggesting either that heterochromatic sequences translocate to the domain surface for replication, or that replication can also occur internally through localized decondensation. To…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}