{
  "id": 829927,
  "title": "Temporal single-cell profiling of the parabrachial Calca neurons reveals molecular dynamics driving nociplastic pain",
  "url": "https://urgent.news/2026/08/13/temporal-single-cell-profiling-of-the-parabrachial-calca-neurons",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-13T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.07.743567v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Parabrachial Calca neurons are necessary for chronic pain and sufficient to drive nociplastic pain in mice, but how they sustain a pain state that outlasts its trigger is unknown. We performed temporal single-cell mRNA sequencing of the parabrachial nucleus (PBN) across the onset, chronic, and recovery phases of Calca neuron-driven tactile allodynia, using fixed-tissue profiling and…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}