{
  "id": 8280426,
  "title": "Model-Free, Pure Component Analysis Could Help Biopharma Cut Costs",
  "url": "https://urgent.news/2026/09/18/model-free-pure-component-analysis-could-help-biopharma-cut-costs",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-18T17:17:11.000Z",
  "source": {
    "name": "GEN Biotechnology",
    "slug": "gen-biotechnology",
    "url": "https://www.genengnews.com/topics/bioprocessing/model-free-pure-component-analysis-could-help-biopharma-cut-costs/"
  },
  "original_language": "en",
  "account": "Spectroscopy aids in real-time analysis of proteins and analytes in process streams. However, many techniques like NIR and Raman depend on models to separate signals from noise. These models are costly and time-consuming to develop, requiring custom experiments and rework when conditions change. Nirrin Technologies, led by Bryan Hassell, proposes an alternative called \"pure-component analysis.\" This model-free approach directly resolves measured spectra into component concentrations, without the need for empirical models or design of experiments (DOE) campaigns. Nirrin's new tunable laser near-infrared (TL-NIR) platform, showcased at BPI East, exemplifies this. With a tunable laser delivering higher optical power to individual wavelengths, TL-NIR offers a significantly higher signal-to-noise ratio than conventional NIR. The TL-NIR platform also provides direct concentrations instead of requiring spectral interpretation, enabling engineers to make decisions based on real-time data. Additionally, TL-NIR proves faster, requiring no sample preparation, dilution, or pathlength adjustments. For protein analysis, TL-NIR is five times faster than variable-pathlength UV and can replace costly HPLC measurements sent to external labs. Currently, five to ten biopharma firms use TL-NIR in development, with plans to raise awareness for commercial production. The technology is already proven in development, with manufacturers gradually adopting it for production.",
  "summary": "Spectroscopic analysis techniques rely on empirical models that are time consuming and expensive to make. Biopharma companies could speed development and reduce costs using a model-free measuring approach called pure-component analysis, says Nirrin Technologies. The post Model-Free, Pure Component Analysis Could Help Biopharma Cut Costs appeared first on GEN - Genetic Engineering and…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}