{
  "id": 8257840,
  "title": "Spatiotemporal control of STING activation and saRNA delivery decouples humoral and cellular immunity",
  "url": "https://urgent.news/2026/09/18/spatiotemporal-control-of-sting-activation-and-sarna-delivery",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-18T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.11.751026v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Self-amplifying mRNA (saRNA) vaccine formulations link the location and timing of antigen expression to innate immune stimulation by both RNA cargo and carrier. We hypothesized that targeting a polymeric STING agonist prodrug (polySTING) to antigen-presenting cells (APCs) independently of saRNA delivery could tune vaccines responses without limiting saRNA expression. By varying the time and…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "Scientific Reports",
        "title": "Intermittent fasting modulates immune signatures but not TNF-dependent pathology in mice with constitutive STING activation",
        "url": "https://urgent.news/2026/09/18/intermittent-fasting-modulates-immune-signatures-but-not-tnf",
        "published": "2026-09-18T00:00:00.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}