{
  "id": 8257836,
  "title": "Notch-independent Her6 contributes to control of neural stem cell maintenance by shifting Notch signaling from lateral inhibition towards lateral induction mode",
  "url": "https://urgent.news/2026/09/18/notch-independent-her6-contributes-to-control-of-neural-stem-cell",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-18T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.16.752018v1?rss=1"
  },
  "original_language": "en",
  "account": "Zebrafish brain research uncovers a crucial role for Her6 in regulating neural stem cell (NSC) maintenance and generation of progenitors. Using lineage-specific scRNA-seq and time series transcriptome analyses, scientists discovered that Her6, a HES1 homolog, independently contributes to NSC regulation alongside Notch signaling. The study found that Her6 and Notch signaling regulate cell cycle genes to control G0/G1 or G2 exit, promoting quiescence. When Her6 and Notch activity work together, they can shift Notch signaling from a lateral inhibition mode driven by Delta and Jagged to a lateral induction mode mediated by Jagged-Notch3. This shift enables Her6 to help maintain persistent NSC patches in ventricular compartments where neurogenesis occurs continuously. Additionally, Her6-dependent lateral induction establishes coherent populations of long-term NSCs in active proliferation zones. In summary, Her6 integrates cell-autonomous lineage-based information and non-autonomous self-organization of neural proliferation zones, playing a pivotal role in balancing NSC maintenance and progenitor generation in the developing brain.",
  "summary": "The growing brain faces the challenge to establish neural stem cell (NSC) populations that accomplish both stable NSC maintenance and dynamic generation of progenitors. Lineage-specific scRNA-seq and time series transcriptome analyses upon overexpression of Notch signaling components in the larval zebrafish brain reveal differential contributions of Notch signaling and Notch-independent Her6, a…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}