{
  "id": 8176855,
  "title": "Integrating structural and biological evidence to rerank ESMFold2 protein-protein interactions",
  "url": "https://urgent.news/2026/09/17/integrating-structural-and-biological-evidence-to-rerank-esmfold2",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-17T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.16.751194v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Large-scale protein structure prediction enables proteome-wide protein-protein interaction (PPI) screening, but distinguishing biologically meaningful interactions from spurious interfaces remains challenging. Here, we develop a scalable framework combining fast, MSA-free ESMFold2 prediction with PAE-guided domain parsing and evidence-based reranking. Three-recycle ESMFold2-Fast achieved 57%…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}