{
  "id": 816846,
  "title": "Loss of Hnf1b in differentiated proximal tubule cells uncovers nephron segment plasticity",
  "url": "https://urgent.news/2026/08/13/loss-of-hnf1b-in-differentiated-proximal-tubule-cells-uncovers",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-13T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.12.744527v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "HNF1B is a transcription factor required for proximal tubule (PT) specification during kidney development, but whether it is also required to maintain PT identity after differentiation remains unknown. Using PT-specific genetic deletion in mice, we found that loss of Hnf1b in differentiated PT cells causes cyst formation and early postnatal lethality. PT-specific transcriptomic analysis revealed…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}