{
  "id": 809874,
  "title": "Structural and functional basis of the non-canonical human Dicer-tRNA complex",
  "url": "https://urgent.news/2026/08/13/structural-and-functional-basis-of-the-non-canonical-human-dicer-trna",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-13T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.12.744379v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Human Dicer (hDicer) is a key enzyme in the RNA interference (RNAi) pathway that generates ~21-22 nt micro-RNA (miRNAs) and small interfering RNAs (siRNAs). We have previously shown that hDicer also generates tRNA-derived small RNAs (tsRNAs), which mediate nuclear gene silencing and regulate hundreds of disease-associated genes. As powerful and evolutionarily conserved cellular regulators, tsRNAs…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}