{
  "id": 8076680,
  "title": "Replication Fork-Associated Checkpoint Mediator Mrc1/Claspin Acts in Arrest-Independent Double-Strand Break Survival",
  "url": "https://urgent.news/2026/09/17/replication-fork-associated-checkpoint-mediator-mrc1-claspin-acts-in",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-17T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751834v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "In budding yeast, the DNA damage checkpoint kinase Mec1ATR is the primary sensor of DSB-associated single-stranded DNA and coordinates cell cycle arrest with DNA repair. Deletion of Mec1 completely abolishes G2/M cell cycle arrest; however, approximately half of mec1{Delta} cells still survive an endonuclease-induced DSB, repairing the DSB either by single-strand annealing or break-induced…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}