{
  "id": 8076674,
  "title": "An Ultrasensitive Luciferase Reporter Reveals Low-Level Extrahepatic mRNA Expression for Enhanced Apparent Biodistribution of Lipid Nanoparticles",
  "url": "https://urgent.news/2026/09/17/an-ultrasensitive-luciferase-reporter-reveals-low-level-extrahepatic",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-17T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751785v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Reporter mRNAs are widely used to screen lipid nanoparticle (LNP) formulations and characterize functional mRNA expression in vivo, yet conventional firefly luciferase (FLuc) imaging fails to detect low-level expression. Consequently, weak or absent FLuc signal can be misinterpreted as failed LNP delivery or translation, potentially excluding formulations and overlooking extrahepatic or…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}