{
  "id": 8076671,
  "title": "Oncogenic fusions induce an extensive cancer-restricted cryptic proteome in Ewing sarcoma",
  "url": "https://urgent.news/2026/09/17/oncogenic-fusions-induce-an-extensive-cancer-restricted-cryptic",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-17T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.16.751792v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "How tumors generate a cryptic \"dark\" proteome absent from healthy tissues, and whether it can be reversibly activated, remains unclear. In Ewing sarcoma, all tumors are driven by EWSR1::ETS fusions, making it a tractable model to study dark proteome activation. Integrating matched transcriptomes, translatomes and proteomes from 48 patient tumors with long-read RNA sequencing, single-cell…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}